Large Grant Guidelines

ASRM Large Grant Cycle Grantee Guidelines

The ASRM Research Institute large grant ($50,000 per year or greater) application cycle opens August 2nd, 2021. We invite investigators to develop research projects addressing fundamental questions of major clinical significance to reproductive medicine. Preference for funding will be given to projects that attempt to answer timely, basic, and clinically relevant questions of potential high impact to the practice of reproductive medicine and which are currently not fundable (either because of applicable existing federal law or because of relatively lower prioritization) by federal funding agencies.

A letter of intent, notifying ASRM of your interest in submitting a full proposal, is due on Nov 1st, 2021. You should receive a confirmation email acknowledging your intent to complete the application process. This email MUST be included in your application pdf to be considered for review.
The ASRM Research Institute funding priorities are listed below. Applications must fall within one of these 4 priorities areas to be considered for committee review.

  • Research projects involving human gametes such as ones aiming to understand human egg maturation; determine single sperm variability to evaluate quality and function in clinical IVF; apply what has been learned from animal models to in vitro gametogenesis in the human; evaluate feasibility and safety of gene editing approaches in human gametes.
  • Research projects involving human embryos such as ones attempting to determine single cell (blastomere, trophectoderm, ICM cell) variability (chromosomal, transcriptomic, metabolomic, etc); define in molecular and cell biological terms cell lineages in the early human embryo; develop methodologies for the evaluation of “stressors” and safety of methodologies in the clinical IVF laboratory; investigate the feasibility and safety of gene editing approaches in human embryos.
  • Research projects evaluating outcomes by developing questionnaires and software for the long-term follow-up of children and their parents following fertility treatments. Building on existing databases and registries is strongly encouraged.
  • Research projects on access to fertility care by developing metrics to evaluate the needs for access to fertility care in low resourced setting(s) or in underrepresented minorities; determine the cost effectiveness and feasibility of easily implementable approaches for the evaluation of fertility status; develop treatment methodologies for cost effective fertility care.

Applicants are encouraged to review the research currently funded page to gain insight into the topical areas of interest and research currently funded by ASRM.


Investigators, meeting eligibility, with expertise in reproductive health and science including endocrinology, biology, urology, epidemiology, embryology, and andrology are encouraged to apply. Eligible applicants include:  

  • Physicians or scientists with track records in basic, clinical, or translational research in reproductive medicine are encouraged to apply.
  • Investigators should have a doctorate degree (MD, MD/PhD, PhD, ScD or equivalent) and have sufficient expertise, commitment of effort, organizational structure, and operational effectiveness to successfully implement the plan for the proposed research.
  • Applicants should have completed their research and/or clinical training for at least three years prior to submitting the application and actively working in the areas related to reproductive medicine.
  • Investigators should hold an independent position as faculty of an accredited medical school or university program (public/state or private), research institute or other non-profit or for-profit organization within the United States focusing on research and/or care of patients with reproductive problems.

Principal investigators responding to this RFA are encouraged to coordinate their submission with others applying to this initiative if their individual projects are complementary. Even though each submission will be reviewed independently, meritorious applications that score high and appear to be related in scope and complementarity are going to be given preference for funding. Applicants are encouraged to highlight such potential interactions between projects in their applications.

Applicants need not be ASRM members at the time of the application but will be required to become members prior to the initiation and throughout the duration of funding. Awardees must maintain an active membership until the project is completed and has been presented at an ASRM annual Scientific Congress.

It is required that any research involving human embryos will comply with applicable federal and state laws and will be in line with the ASRM’s guidance document on the ethics of human embryo research. No research will proceed without all relevant Institutional Board(s) and Committee(s) reviews and approval.

Progress Reports

Biannual progress reports are required and will be reviewed by the ASRM Research Institute. Confirmation of progress report acceptance will be provided via email. Continued funding will depend on adequate and demonstrated progress and productivity as well as compliance with progress report timelines and any regulatory requirements.

Award Budget

Up to $250,000 per year per funded application including up to 10% covering overhead costs. Funds may be used for support of a new or ongoing research/clinical investigation project. No clinical care costs will be covered by this funding opportunity.

Award Project Period

THREE years


An application must include the following information in order as described below. Additionally, all letters must be included in your application package and cannot be sent separately or post application deadline. Please note: Letters outside the required department head or program chair letters are not required but you may submit up to 2 additional letters of support from collaborators/key personnel.

  1. Title page
    1. Title of the project (not to exceed 200 characters including spaces)
    2. Applicant’s name and credentials
    3. Applicant’s, department affiliation and sponsoring institution.
    4. Contact information including mailing address, telephone number and email
    5. Total funding amount requested
  2. Letters
    1. Applicant letter stating career goals and plans for achieving these goals., including a lay statement of 2-3 sentences describing the relevance of the proposed research.
    2. Chairman letter (no more than two pages) acknowledging the applicant’s project and grant proposal, endorsing the applicant’s research, and confirming the institution’s commitment to provide time and support to the applicant.
  3. ASRM Confirmation email
    A copy of the ASRM letter of intent confirmation email must accompany your application
  4. Abstract (One page maximum)
    1. Scientific Abstract (500 words) describing the research proposal including the potential immediate impact of the anticipated results on the practice of reproductive medicine.
    2. Lay-person Abstract (200 words) describing the project in general terms
  5. Specific Aims of the research proposal presented in NIH format– (One page maximum).
  6. A research proposal should include the following sections (no more than five pages)
    1. Background and Significance
    2. Innovation and Potential Impact
    3. Research Plan (methodology and statistical analysis plan must be clearly described)
    4. Timeline for project start up, implementation, and completion
  7. NIH-style Biosketch 
    A biosketch for each primary or co-investigator should be provided. Each Biosketch should include a specific description of the role of each investigator in the proposed project and should not exceed FIVE pages (including the current funding).
  8. Budget
    1. A detailed yearly and cumulative budget and budget justification for the project.
    2. No clinical care costs will be covered by this funding opportunity.
    3. Funds are available for project expenses, technical assistance, patient expenses, research supplies and durable laboratory equipment, analysis software, national registries, survey licenses, etc.
    4. Funds may not be used towards degree seeking courses
    5. Travel expenses, investigator’s salary and/or benefits will be allowed but must not exceed 10% of the grant distribution.
    6. Indirect costs are allowable but are capped at 10% for the entire project.
  9. Formatting
    1. The proposal must be typed in Cambria 12 pt. type with page margins no less than .5 inches and no more than 1 inch.
    2. Pagination should be included at the bottom of each page (excluding the Title page).
    3. Letter of Intent confirmation email MUST be included in your application pdf to be considered for review
    4. The entire application must be submitted as ONE PDF FILE to by 4pm EST on February 15th, 2022. SUBJECT LINE: Large Grant Application Submission
  10. Regulatory requirements
    Human and/or animal use must be approved by the Institutional Review Board or Institutional Animal Care and Use Committee, or their equivalent and documented before funds are released, but pre-approval is not required for application.